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Conformational transition of Aβ42 inhibited by a mimetic peptide. A molecular modeling study using QM/MM calculations and QTAIM analysis
(Elsevier, 2016-03)
The main pathogenic event in Alzheimer's disease is believed to be the aggregation of the amyloid β-peptides into toxic aggregates. In a previous work we designed a mimetic peptide possessing a significant aggregation ...
Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β 42 monomer
(Academic Press Inc Elsevier Science, 2018-12)
A series of novel mimetic peptides were designed, synthesised and biologically evaluated as inhibitors of Aβ 42 aggregation. One of the synthesised peptidic compounds, termed compound 7 modulated Aβ 42 aggregation as ...
New mimetic peptides inhibitors of Аb aggregation. Molecular guidance for rational drug design
(Elsevier, 2015-05)
A new series of mimetic peptides possessing a significant Aβ aggregation modulating effect was reported here. These compounds were obtained based on a molecular modelling study which allowed us to perform a structural-based ...
Clinical Approaches to Preserve beta-Cell Function in Diabetes
(SPRINGER-VERLAG BERLIN, 2010)
In type 2 diabetes (DM2) there is progressive deterioration in beta-cell function and mass. It was found that islet function was about 50% of normal at the time of diagnosis and reduction in beta-cell mass of about 60% at ...
Protease inhibitory, insecticidal and deterrent effects of the trypsin- inhibitor benzamidine on the velvetbean caterpillar in soybean
(Anais da Academia Brasileira de Ciências, 2019)
Peptídeo mimético ao inibidor de PLA2 como uma nova ferramentapara o tratamento da asma A mimetic PLA2 inhibitor peptide as a novel tool for asthma treatment
(Universidade Federal de UberlândiaBrasilPrograma de Pós-graduação em Imunologia e Parasitologia Aplicadas, 2019)
Desenvolvimento de peptídeos miméticos a um inibidor de Fosfolipases A2 por Phage Display com potencial para aplicações terapêuticasDevelopment of Phospholipase A2 inhibitor mimetic peptides by Phage Display with potential for therapeutic applications
(Universidade Federal de UberlândiaBrasilPrograma de Pós-graduação em Genética e Bioquímica, 2022)
Adepamycin: design, synthesis and biological properties of a new peptide with antimicrobial properties
(Elsevier B.V., 2020-09-30)
Antimicrobial peptides (AMP) are molecules with a broad spectrum of activities that have been identified in most living organisms. In addition, synthetic AMPs designed from natural polypeptides have been largely investigated. ...
HsDHODH Microdomain-Membrane Interactions Influenced by the Lipid Composition
(2017-12-14)
Human dihydroorotate dehydrogenase (HsDHODH) enzyme has been studied as selective target for inhibitors to block the enzyme activity, intending to prevent proliferative diseases. The N-terminal microdomain seems to play ...